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Both are FDA-approved for chronic weight management in adults who meet certain criteria, but tirzepatide targets both GIP and GLP-1 pathways, while semaglutide targets GLP-1
The peptide, made from human gastric juice, is not approved for clinical use in any country (13)
doi:10.1097/YIC.0000000000000595
In response to lipopolysaccharide stimulation, exendin-4 reduced the expression of IL-1 and TNF- in these cells (85)
doi:10.1152/ajpendo.00201.2006 (source) Ionescu M, Frohman LA
Together, they can lead to more profound and stable blood sugar regulation, which is especially beneficial for individuals with poorly controlled type 2 diabetes
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